SLC6A4 · Serotonin transporter (SERT)
Major depressive disorder · Mean pLDDT 84.69
Structure lab
Human protein models linked to a specific study in each research program. Open a record to rotate the structure, inspect residue confidence and read the cited study.
12 results
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SLC6A3 · Dopamine transporter (DAT)
Attention-deficit/hyperactivity disorder · Mean pLDDT 86.95
HTR1A · 5-HT1A receptor
Generalized anxiety disorder · Mean pLDDT 77.81
CACNA1C · CaV1.2 calcium-channel subunit
Schizophrenia · Bipolar disorder · Mean pLDDT 61.93
GRIN2A · NMDA receptor subunit GluN2A
Schizophrenia · Mean pLDDT 60.85
SCN2A · NaV1.2 sodium channel
Autism spectrum disorder · Bipolar disorder · Mean pLDDT 68.79
CHD8 · Chromodomain helicase DNA-binding protein 8
Autism spectrum disorder · Mean pLDDT 53.92
SHANK3 · Postsynaptic scaffold protein SHANK3
Autism spectrum disorder · Mean pLDDT 52.42
CRHR1 · Corticotropin-releasing hormone receptor 1
Post-traumatic stress disorder · Mean pLDDT 77.32
WDR6 · WD repeat-containing protein 6
Obsessive-compulsive disorder · Mean pLDDT 85.33
DALRD3 · DALR anticodon-binding domain-containing protein 3
Obsessive-compulsive disorder · Mean pLDDT 87.85
CTNND1 · Catenin delta-1
Obsessive-compulsive disorder · Mean pLDDT 65.05
Interpreting confidence
pLDDT estimates local confidence for each residue. Predicted aligned error (PAE) addresses confidence in relative placement. Follow the AlphaFold DB entry for its PAE viewer and original file. This lab displays the backbone trace and per-residue pLDDT.
The models represent reference protein sequences. Disease associations, functional variant effects and drug binding each require evidence at the corresponding level. The research link on each record identifies which type of evidence was used.