HTR1A

5-HT1A receptor

AF-P08908-F1 · v6 · Human reference sequence 1–422

Predicted backbone

Drag to rotate, or use the arrow keys on the model. Select a residue below to inspect its pLDDT.

The original model and trace download are linked below.

≥9070–<9050–<70<50

Research links

Generalized anxiety disorder

Pharmacological target

A cryo-EM study resolves buspirone in a human 5-HT1A–Gi1 complex. It links the receptor to an anxiolytic drug through binding pharmacology.

Warren et al., 2024

Experimental structure

Human 5-HT1A–Gi1 complex with buspirone, cryo-EM, 2.62 Å.

PDB 8FYX

Provenance and confidence

AlphaFold DB prediction by Google DeepMind and EMBL-EBI. The viewer draws a Cα trace derived from the RCSB BinaryCIF copy. We matched the release, residue sequence and mean pLDDT against AlphaFold DB.

Model: AF-P08908-F1 · v6
Retrieved: 2026-11-14
Mean pLDDT: 77.81 / 100
Residues by band: ≥90 · 218 / 70–<90 · 87 / 50–<70 · 21 / <50 · 96
Coordinate SHA-256: 3a0fbc713477c306ff099089b89bc9769e4604ffefac6183fd96bcb60feca3a1
License: CC BY 4.0

AlphaFold entry and PAE viewer RCSB model BinaryCIF coordinates Trace JSON

Varadi et al. · AlphaFold DB