SCN2A
NaV1.2 sodium channel
AF-Q99250-F1 · v6 · Human reference sequence 1–2,005
Predicted backbone
The original model and trace download are linked below.
≥9070–<9050–<70<50
Research links
Autism spectrum disorder
Rare variant study
Electrophysiological assays of SCN2A variants identified in autism probands observed reduced NaV1.2 function in the variants studied.
Bipolar disorder
Genetic association candidate
Fine-mapping with functional annotations prioritizes SCN2A in a separate bipolar disorder GWAS analysis.
Provenance and confidence
AlphaFold DB prediction by Google DeepMind and EMBL-EBI. The viewer draws a Cα trace derived from the RCSB BinaryCIF copy. We matched the release, residue sequence and mean pLDDT against AlphaFold DB.
- Model
- AF-Q99250-F1 · v6
- Retrieved
- Mean pLDDT
- 68.79 / 100
- Residues by band
- ≥90 · 335 / 70–<90 · 913 / 50–<70 · 241 / <50 · 516
- Coordinate SHA-256
56ed2f32446671be65666f101cf00e80a9854671e9decdcf89a88db24aa6d4df- License
- CC BY 4.0